Publications by denishaine
Veterinary Epidemiologic Research: GLM (part 4) – Exact and Conditional Logistic Regressions
Next topic on logistic regression: the exact and the conditional logistic regressions. Exact logistic regression When the dataset is very small or severely unbalanced, maximum likelihood estimates of coefficients may be biased. An alternative is to use exact logistic regression, available in R with the elrm package. Its syntax is based on an even...
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Veterinary Epidemiologic Research: Count and Rate Data – Poisson & Negative Binomial Regressions
Still going through the book Veterinary Epidemiologic Research and today it’s chapter 18, modelling count and rate data. I’ll have a look at Poisson and negative binomial regressions in R. We use count regression when the outcome we are measuring is a count of number of times an event occurs in an individual or group of individuals. We will u...
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Veterinary Epidemiologic Research: Count and Rate Data – Zero Counts
Continuing on the examples from the book Veterinary Epidemiologic Research, we look today at modelling count when the count of zeros may be higher or lower than expected from a Poisson or negative binomial distribution. When there’s an excess of zero counts, you can fit either a zero-inflated model or a hurdle model. If zero counts are not poss...
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Veterinary Epidemiologic Research: Count and Rate Data – Poisson Regression and Risk Ratios
As noted on paragraph 18.4.1 of the book Veterinary Epidemiologic Research, logistic regression is widely used for binary data, with the estimates reported as odds ratios (OR). If it’s appropriate for case-control studies, risk ratios (RR) are preferred for cohort studies as RR provides estimates of probabilities directly. Moreover, it is often...
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Veterinary Epidemiologic Research: Modelling Survival Data – Non-Parametric Analyses
Next topic from Veterinary Epidemiologic Research: chapter 19, modelling survival data. We start with non-parametric analyses where we make no assumptions about either the distribution of survival times or the functional form of the relationship between a predictor and survival. There are 3 non-parametric methods to describe time-to-event data: a...
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Veterinary Epidemiologic Research: Modelling Survival Data – Semi-Parametric Analyses
Next on modelling survival data from Veterinary Epidemiologic Research: semi-parametric analyses. With non-parametric analyses, we could only evaluate the effect one or a small number of variables. To evaluate multiple explanatory variables, we analyze data with a proportional hazards model, the Cox regression. The functional form of the baseline...
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Veterinary Epidemiologic Research: Modelling Survival Data – Parametric and Frailty Models
Last post on modelling survival data from Veterinary Epidemiologic Research: parametric analyses. The Cox proportional hazards model described in the last post make no assumption about the shape of the baseline hazard, which is an advantage if you have no idea about what that shape might be. With a parametric survival model, the survival time is ...
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Bias in Observational Studies – Sensitivity Analysis with R package episensr
When it’s time to interpret the study results from your observational study, you have to estimate if the effect measure you obtained is the truth, if it’s due to bias (systematic error, the effect measure’s precision), or if it’s due to chance (random error, the effect measure’s validity) (Rothman and Greenland, 2008, pp115-134). Every ...
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