Publications by Charleen Adams

Genetic Correlations between UKB-PPP Chemokines

1 Introduction This analysis uses linkage disequilibrium score regression (LDSC) to obtain genetic correlations (rgs) between Olink chemokines. LDSC requires LD scores (r2) values (vs SuSiE and coloc which use the signed correlation, r). We are starting with the UKB Olink proteins because the Alkes lab has precalcuated LD scores for Europeans. We�...

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SuSiE PCSK9

1 Introduction This analysis investigates the potential genetic overlap between proprotein convertase subtilisin/kexin type 9 (PCSK9) and Body Mass Index (BMI) using summary statistics, SuSiE fine-mapping, and colocalization analysis. We focus on a 500KB region upstream and downstream of the sentinel SNP rs147852470 and include only variants with a...

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Analysis of N-Acetyltaurine and BMI with SuSiE and Colocalization

1 Introduction This analysis investigates the potential genetic overlap between N-acetyltaurine (NAT) and Body Mass Index (BMI) using summary statistics, SuSiE fine-mapping, and colocalization analysis. We focus on a 500KB region upstream and downstream of the sentinel SNP rs147852470. 2 Data Preparation 2.1 Load the Merged Summary Statistics We ...

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